Yes, the new Pratchett is very different. For one thing, it is a great deal more serious* than many of his past books. It also takes place (kind of) in our world, rather than the disc world. Still, it is a very good story and told well. With his usual gimlet eye Pratchett takes on colonialism and white superiority. Go into it expecting an exciting and imaginative tale, but not your standard Pratchett fare.
* for Pratchett